schizophrenia (skĭt´sə-frēʹnē-ə, -frĕnʹē-ə) noun. 1. Any of a group of psychotic disorders usually characterized by withdrawal from reality, illogical patterns of thinking, delusions, and hallucinations, and accompanied in varying degrees by other emotional, behavioral, or intellectual disturbances. Schizophrenia, often associated with dopamine imbalances in the brain and defects of the frontal lobe, may have an underlying genetic cause, (penyakit) skizofrenia; 2. (colloquial) inconsistency, perangai yang berubah-ubah.